کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9278656 | 1593136 | 2005 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy](/preview/png/9278656.png)
چکیده انگلیسی
Purine salvage is an essential function for all obligate parasitic protozoa studied to date and most are also capable of efficient uptake of preformed pyrimidines. Much progress has been made in the identification and characterisation of protozoan purine and pyrimidine transporters. While the genes encoding protozoan or metazoan pyrimidine transporters have yet to be identified, numerous purine transporters have now been cloned. All protozoan purine transporter-encoding genes characterised to date have been of the Equilibrative Nucleoside Transporter family conserved in a great variety of eukaryote organisms. However, these protozoan transporters have been shown to be sufficiently different from mammalian transporters to mediate selective uptake of therapeutic agents. Recent studies are increasingly addressing the structure and substrate recognition mechanisms of these vital transport proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Microbiology Reviews - Volume 29, Issue 5, November 2005, Pages 987-1020
Journal: FEMS Microbiology Reviews - Volume 29, Issue 5, November 2005, Pages 987-1020
نویسندگان
Harry P. de Koning, Daniel J. Bridges, Richard J.S. Burchmore,