کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9282141 1224381 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tolérance et interactions médicamenteuses des traitements anti-VIH et anti-VHC
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
پیش نمایش صفحه اول مقاله
Tolérance et interactions médicamenteuses des traitements anti-VIH et anti-VHC
چکیده انگلیسی
Treating Hepatitis C among HIV patients under antiretroviral drug therapy requires a high degree of vigilance and continuous monitoring because of frequent problems with intolerance and/or drug interactions. Recent studies, including three therapeutic trials, on Ribavic, APRICOT, and ACTG A5671, have given some insights on following these patients up. The adverse effects are relatively similar in HCV-HIV-co-infected patients and patients infected by HCV only. Their frequency is, on the other hand, higher among HCV-HIV-Co-infected patients. The adverse-effects are consistent, in a non-exhaustive way, with pseudo influenza-like symptoms, fever, myalgia, cephalgia, with psychiatric disorders (irritability, depression, etc.); endocrine disorders (thyroid dysfunction, diabetes...); and with hematological anomalies especially anemia and leucopenia. But the percentage of lymphocyte T CD4 is not modified, therefore there is no risk of opportunistic infection. Pharmacokinetic interactions between antiretroviral drugs and treatment for HCV infection including ribavirin plus interferon alpha (IFN-alpha) or pegylated IFN are described. They are almost exclusively due to the combination of ribavirin and of nucleoside analogue reverse transcriptase inhibitors. One of the principal consequences is the emergence of mitochondrial toxicity defined by the occurrence of hyperlactatemia, or acute pancreatitis). Thus, some combinations should be avoided such as ddI + ribavirin and ddI + d4T + ribavirin. The d4T + ribavirin combination must also be used with caution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Médecine et Maladies Infectieuses - Volume 35, Issue 3, March 2005, Pages 135-140
نویسندگان
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