کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296409 | 1233530 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Animal models of hypertension: An overview
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کلمات کلیدی
ANP2K1CPRAANGIIAT1DOCAeNOSRASACEangiotensin II type 1 receptor - آنژیوتانسین II نوع 1 گیرندهAngiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمAngiotensin II - آنژیوتانسین دوendothelin - اندوتلینSpontaneously Hypertensive Rat - خودآزمایی موش بالینیendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالrenin-angiotensin system - سیستم رنین-آنژیوتانسینShr - شریPlasma renin activity - فعالیت رنین پلاسماNitric oxide - نیتریک اکسیدatrial natriuretic peptide - پپتید نایروئیدوری دهلیزAdrenergic receptors - گیرنده های آدرنرژیک
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hypertension is a multifactorial disease involving complex interactions between genetic and environmental factors. Development of experimental models of hypertension allowed dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits, and cellular responses to injury. The phenotype-driven approach is taking advantage of selective breeding of animals (primarily rats) that exhibit a desired phenotype, like the useful SHR. Genotype-driven models include transgenic techniques, in which mice are the most successful for selective deletion or overexpression of target genes. Notably, a combination of comparative genomics strategies and phenotypic correlates enhances the utility of hypertension models and their clinical relevance. Indeed, experimental models enabled development of targeted interventions aimed at decreasing not only blood pressure but also target organ injury. Continued utilization of experimental models simulating human hypertension, particularly those that combine other clinically relevant comorbidities like obesity or hypercholesterolemia, may afford development of effective strategies to address this common disease. Nevertheless, a cautious approach is mandatory when experimental findings in these models are extrapolated to human hypertension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 146, Issue 3, September 2005, Pages 160-173
Journal: Journal of Laboratory and Clinical Medicine - Volume 146, Issue 3, September 2005, Pages 160-173
نویسندگان
Lilach O. Lerman, Alejandro R. Chade, Vincenzo Sica, Claudio Napoli,