Individual variability in brain activations associated with episodic retrieval: A role for large-scale databases

The localization of brain functions using neuroimaging techniques is commonly dependent on statistical analyses of groups of subjects in order to identify sites of activation, particularly in studies of episodic memory. Exclusive reliance on group analysis may be to the detriment of understanding the true underlying cognitive nature of brain activations. In this overview, we found that the patterns of brain activity associated with episodic retrieval are very distinct for individual subjects from the patterns of brain activity at the group level. These differences appear to go beyond the relatively small variations due to cyctoarchitectonic differences or spatial normalization. We review evidence that individual patterns of brain activity vary widely across subjects and are reliable over time despite extensive variability. We suggest that varied but reliable individual patterns of significant brain activity may be indicative of different cognitive strategies used to produce a recognition response. We argue that individual analyses in conjunction with group analyses are likely to be critical in fully understanding the relationship between retrieval processes and underlying neural systems.