Prospective, Randomized, Multicentric, Open, Comparative Study on the Efficacy of a Prophylactic Single Dose of 500Â mg Levofloxacin versus 1920Â mg Trimethoprim/Sulfamethoxazole versus a Control Group in Patients Undergoing TUR of the Prostate

It is debatable whether postoperative bacteriuria is the key parameter to define efficacy of antimicrobial prophylaxis in patients undergoing TUR-P. The rate of bacteriuria, however, correlated well with the overall rate of postoperative complications. Therefore, it seems reasonable to lower the rate of bacteriuria by prophylaxis. Since patients without antibiotic prophylaxis received at the end even more antibiotic doses than patients with prophylaxis, the overall selection pressure by antibiotic usage can obviously not be lowered by resigning prophylaxis. Therefore we conclude that at least patients at risk should receive antibiotic prophylaxis prior to TUR-P.