کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
936452 1475152 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in a Murine Model of Complex Regional Pain Syndrome
ترجمه فارسی عنوان
اختلالات جنسی در یک مدل مردانه سندرم درد پیچیده منطقه ای
کلمات کلیدی
سندرم درد پیچیده منطقه ای، درد مزمن، کمبود حافظه مربوط به درد، تفاوت جنسی در درد، حساسیت مرکزی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• CRPS is characterized by severe pain and associated cognitive dysfunction.
• CRPS exhibits high female prevalence; females are affected 3 times more than males.
• Pre-clinically, female mice show lower nociceptive thresholds compared to males.
• Female mice show deficits in fear memory and signs of latent sensitization.
• These behavioral differences are associated with changes in spinal Nr2b levels.

Complex Regional Pain Syndrome (CRPS) is a major cause of chronic pain after surgery or trauma to the limbs. Despite evidence showing that the prevalence and severity of many forms of chronic pain, including CRPS, differ between males and females, laboratory studies on sex-related differences in animal models of CRPS are not available, and the impact of sex on the transition from acute to chronic CRPS pain and disability are unexplored. Here we make use of a tibia fracture/cast mouse model that recapitulates the nociceptive, functional, vascular, trophic, inflammatory and immune aspects of CRPS. Our aim is to describe the chronic time course of nociceptive, motor and memory changes associated with fracture/cast in male and female mice, in addition to exploring their underlying spinal mechanisms. Our behavioral data shows that, compared to males, female mice display lower nociceptive thresholds following fracture in the absence of any differences in ongoing or spontaneous pain. Furthermore, female mice show exaggerated signs of motor dysfunction, deficits in fear memory, and latent sensitization that manifests long after the normalization of nociceptive thresholds. Our biochemical data show differences in the spinal cord levels of the glutamate receptor NR2b, suggesting sex differences in mechanisms of central sensitization that could account for differences in duration and severity of CRPS symptoms between the two groups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 123, September 2015, Pages 100–109
نویسندگان
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