کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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936689 | 1475179 | 2012 | 8 صفحه PDF | دانلود رایگان |
Several molecules were recently found to be important for the memory retrieval process in the hippocampus; however, the mechanisms underlying the memory retrieval remain poorly understood. GSK-3β has been implicated in the control of synaptic plasticity and memory formation. Here, we investigated the relationship between hippocampal GSK-3β activity and memory retrieval using behavioral and Western blotting methods. We found that GSK-3β was activated in the hippocampus after a retention session in the passive avoidance task. An intrahippocampal injection of the GSK-3β inhibitor, SB 216763, before the retention session blocked memory retrieval (but not reconsolidation) without affecting locomotor activity. These results suggest that GSK-3β activation would be essential for memory retrieval in the hippocampus.
► GSK-3β in the hippocampus was activated by memory retrieval in the passive avoidance task.
► Inhibition of GSK-3β activity impaired memory retrieval.
► Inhibition of GSK-3β activity did not affect memory reconsolidation.
Journal: Neurobiology of Learning and Memory - Volume 98, Issue 2, September 2012, Pages 122–129