کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
936941 | 1475199 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus](/preview/png/936941.png)
Olfaction has particular links with learning and memory compared with other sensory cues, due to the interrelations between their neural circuitry. The present study deals with the effects of a putative stressor (i.e. a predator odor) on visuo-spatial learning in mice. Firstly, the results show that a predator odor spread during the Morris water maze task led to learning enhancement. In addition, a stereotaxic approach was used to investigate the involvement of the amygdala in this hippocampus-dependent type of learning. Thus, the performance of mice in visuo-spatial learning under predator odor conditions was dramatically reduced by an ibotenate bilateral amygdala lesion. The involvement of the amygdala was confirmed by a reduced expression of c-fos in the CA1 hippocampus of amygdala-lesioned mice at the end of the learning procedure.Mild exposure to a predator odor during hippocampus-dependent learning therefore leads to an enhancement of performance through the co-activation of the amygdala, probably by a stress mediated mechanism.
Journal: Neurobiology of Learning and Memory - Volume 93, Issue 2, February 2010, Pages 196–202