کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937007 1475208 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Actin polymerization in lateral amygdala is essential for fear memory formation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Actin polymerization in lateral amygdala is essential for fear memory formation
چکیده انگلیسی

Actin polymerization is involved in key neuronal functions such as intracellular trafficking and morphogenesis. In this study, we examined the role of actin polymerization in lateral amygdala (LA) in fear conditioning memory formation. Microinfusion of cytochalasin D, an actin polymerization inhibitor, into rat LA immediately before fear conditioning training impaired the formation of long-term fear memory (LTM) but not short-term fear memory (STM). Microinfusion of cytochalasin D into rat LA immediately after fear conditioning impaired LTM. Cytochalasin D had no effect on fear conditioning memory retrieval when injected immediately before LTM test. These results show that actin cytoskeleton rearrangement is essential for fear memory consolidation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 91, Issue 1, January 2009, Pages 85–88
نویسندگان
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