Chronic fatigue syndrome in children

Chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) is a heterogeneous condition that causes significant morbidity in young people. Its cause is unknown with current evidence suggesting that, in mild and moderate cases, cognitive behaviour therapy and/or graded exercise should be the treatment of choice. The majority of adolescents will improve or get better. Further research is required to determine aetiology and optimum management.