کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937658 924529 2010 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurobehavioral evidence for changes in dopamine system activity during adolescence
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Neurobehavioral evidence for changes in dopamine system activity during adolescence
چکیده انگلیسی

Human adolescence has been characterized by increases in risk-taking, emotional lability, and deficient patterns of behavioral regulation. These behaviors have often been attributed to changes in brain structure that occur during this developmental period, notably alterations in gray and white matter that impact synaptic architecture in frontal, limbic, and striatal regions. In this review, we provide a rationale for considering that these behaviors may be due to changes in dopamine system activity, particularly overactivity, during adolescence relative to either childhood or adulthood. This rationale relies on animal data due to limitations in assessing neurochemical activity more directly in juveniles. Accordingly, we also present a strategy that incorporates molecular genetic techniques to infer the status of the underlying tone of the dopamine system across developmental groups. Implications for the understanding of adolescent behavioral development are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 34, Issue 5, April 2010, Pages 631–648
نویسندگان
, , ,