کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937763 924538 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Receptor trafficking induced by μ-opioid-receptor phosphorylation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Receptor trafficking induced by μ-opioid-receptor phosphorylation
چکیده انگلیسی

Opiates, including morphine, are widely used drugs for antinociception in clinics. Prolonged treatments of opioids induce both tolerance and dependence, which are the major side effects of opioid therapy. One of the mechanisms for the development of tolerance and dependence is implicated to be opioid-receptor trafficking. Here we review the current understandings of opioid-receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments. Also, the role of G-protein coupled receptor kinases in opioid-receptor phosphorylation is discussed. How to associate these observations to physiological and behavioral changes in animal models and clinics is still under investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 33, Issue 8, September 2009, Pages 1192–1197
نویسندگان
, , , , ,