کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937815 924545 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The HR/LR model: Further evidence as an animal model of sensation seeking
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The HR/LR model: Further evidence as an animal model of sensation seeking
چکیده انگلیسی

Sensation seeking is a personality trait characterized by risk-taking and the desire to experience novel stimuli. Evidence suggests that sensation seeking may increase an individual's psychological and neurobiological vulnerabilities to drug abuse. One potential animal model of human sensation seeking is high response to novelty in rats. High responders (HRs) prefer a novel environment to a familiar one and show an increase in locomotor activity in the new environment. These rats also show lower levels of anxiety-like behaviour on several tests. Furthermore, HRs display a much higher propensity to self-administer psychostimulants compared to low responders (LRs). HR rats and sensation seeking humans share a number of similarities, for instance both exhibit elevated mesolimbic dopamine activity, which has been implicated in central reward signaling and drug addiction. Evidence of common behavioural tendencies, physiological responses and gene expression patterns suggest that the HR model could be used as an animal model to investigate substance abuse in sensation seeking humans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 33, Issue 7, July 2009, Pages 1145–1154
نویسندگان
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