کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937990 924567 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CNS-active drugs in aging population at high risk of cerebrovascular events: Evidence from preclinical and clinical studies
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
CNS-active drugs in aging population at high risk of cerebrovascular events: Evidence from preclinical and clinical studies
چکیده انگلیسی

The recovery process following cerebral insults such as stroke is affected by aging and pharmacotherapy. The use of medication including CNS-active drugs has increased in the elderly during recent years. However, surprisingly little is known about how safe they are with respect to severity of sensorimotor and cognitive impairments or recovery of function following possible cerebrovascular accidents. This review examines the experimental and clinical literature, primarily from 1995 onwards, concerning medication in relation to cerebrovascular events and functional recovery. Special attention is directed to polypharmacy and to new CNS-active drugs, which the elderly are already taking or are prescribed to treat emerging, stroke-induced psychiatric symptoms. The neurobiological mechanisms affected by these drugs are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 32, Issue 1, 2008, Pages 56–71
نویسندگان
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