The Immunologic Function of 1B2+ Double Negative (CD4−CD8−) T Cells in the 2C Transgenic Mouse1

In the periphery of transgenic 2C mice is a unique CD4−CD8− population of T cells bearing the transgenic specific marker 1B2. These non-cytotoxic cells can be optimally stimulated to develop marked specific Ld cytotoxicity in parallel with the expression of the CD8+ epitope.