The integrin α5β1 regulates αvβ3-mediated extracellular signal-regulated kinase activation1

Signaling through the ERK/MAPK pathway is required for efficient αvβ3-mediated migration on FBG. Inhibition of αvβ3-mediated migration by the integrin α5β1 correlates with altered intensity and duration of ERK/MAPK activation, but not FAK activation, in response to adhesion. This suggests a mechanism for the regulatory effect of α5β1 on αvβ3-mediated cell migration.