کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9406791 | 1290139 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pilocarpine prevents age-related spatial learning impairments in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
The purpose of this work was to evaluate whether a single administration of the muscarinic receptor agonist Pilocarpine (Pilo) could prevent the age-related learning impairment in rats. Three groups of animals received Pilo (300Â mg/kg, i.p.), at 3 months of age, and the animals that did not show Status epilepticus were submitted to the water maze task 1 or 21 months after or once a month from the 4th to 24th month of age. The results showed that Pilo did not interfere with learning abilities 1-month after treatment nor in animals that were submitted to the test once a month. In addition, the animals treated with Pilo and submitted to the task 21 month after performed as well as control young rats in the training and in the testing sessions, while a marked learning impairment was detected in control old rats. These results indicate that a single administration of Pilo might prevent the age-related learning impairments in rats on a spatial task in the water maze.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 158, Issue 2, 30 March 2005, Pages 263-268
Journal: Behavioural Brain Research - Volume 158, Issue 2, 30 March 2005, Pages 263-268
نویسندگان
Nelson De-Mello, Iran Q. Souza-Junior, Antonio P. Carobrez,