کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9409534 | 1290881 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Steady-dose and escalating-dose “binge” administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
This study examined the effects of chronic (14-day) steady-dose and escalating-dose “binge” pattern cocaine administration on striatal preprodynorphin (ppDyn) mRNA levels and behavioral stereotypies. Animals in the steady-state and escalating groups received cocaine in a “binge” pattern (three equal injections starting 30Â min following the start of the daily light cycle, separated by 1Â h). The dose of cocaine in the “steady-dose” group was 15Â mg/kg/injection and remained constant throughout the study. The escalating group received 15Â mg/kg/injection on days 1-3, 20Â mg/kg/injection on days 4-6, 25Â mg/kg/injection on days 7-9 and 30Â mg/kg/injection thereafter, for a maximum daily dose of 90Â mg/kg. Levels of ppDyn mRNA were determined by solution hybridization. Cocaine significantly affected body weight. Both steady-dose and escalating-dose “binge” cocaine administration resulted in expression of behavioral stereotypy and induced intense, rapid head movements which were dose- and time-dependent. Cocaine, independent of dose, increased ppDyn mRNA levels in the caudate putamen (CPu), but not in the nucleus accumbens (NAc). These data suggest that the ppDyn response to cocaine in the CPu is not dose-dependent or that it has reached a maximal level at the 45Â mg/kg daily dose.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 67, Issue 3, 15 October 2005, Pages 169-175
Journal: Brain Research Bulletin - Volume 67, Issue 3, 15 October 2005, Pages 169-175
نویسندگان
Stefan D. Schlussman, Yan Zhou, Alexis Bailey, Ann Ho, Mary Jeanne Kreek,