کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410614 | 1291268 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α1-Adrenoreceptor in human hippocampus: Binding and receptor subtype mRNA expression
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کلمات کلیدی
Neurotransmitters, modulators, transporters and receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاSignal transduction: gene expression - انتقال سیگنال: بیان ژنIn situ - در سایتnorepinephrine - نوراپی نفرینHippocampus - هیپوکامپ prazosin - پرازوسینReceptor binding - گیرنده گیرنده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
α1-Adrenoreceptors (AR), of which three subtypes exist (α1A-, α1B- and α1D-AR) are G-protein-coupled receptors that mediate the actions of norepinephrine and epinephrine both peripherally and centrally. In the CNS, α1-ARs are found in the hippocampus where animal studies have shown the ability of α1-AR agents to modulate long-term potentiation and memory; however, the precise distribution of α1-AR expression and its subtypes in the human brain is unknown making functional comparisons difficult. In the human hippocampus, 3H-prazosin (α1-AR antagonist) labels only the dentate gyrus (molecular, granule and polymorphic layers) and the stratum lucidum of the CA3 homogenously. Human α1A-AR mRNA in the hippocampus is observed only in the dentate gyrus granule cell layer, while α1D-AR mRNA expression is observed only in the pyramidal cell layers of CA1, CA2 and CA3, regions where 3H-prazosin did not bind. α1B-AR mRNA is not expressed at detectable levels in the human hippocampus. These results confirm a difference in hippocampal α1-AR localization between rat and humans and further describe a difference in the localization of the α1A- and α1D-AR mRNA subtype between rats and humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 139, Issue 2, 3 October 2005, Pages 367-371
Journal: Molecular Brain Research - Volume 139, Issue 2, 3 October 2005, Pages 367-371
نویسندگان
Patricia Szot, Sylvia S. White, J. Lynne Greenup, James B. Leverenz, Elaine R. Peskind, Murray A. Raskind,