کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410628 | 1291269 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression and localization of NK1R, substance P and CGRP are altered in dorsal root ganglia neurons of spontaneously hypertensive rats (SHR)
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کلمات کلیدی
CGRPNK1Neurotransmitters, modulators, transporters and receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاSubstance P - ماده PReceptor modulation, up- and down-regulation - مدولاسیون گیرنده، تنظیم بالا و پایینDorsal root ganglia (DRG) - گانگلیس ریشه پشتی (DRG)NK1 receptor - گیرنده NK1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The kidneys play a pivotal role in the pathogenesis of essential hypertension because of a primary defect in renal hemodynamics and/or tubule hydro-saline handling that results in the retention of fluid and electrolytes. Previous studies have shown that increasing the renal pelvic pressure increased ipsilateral afferent renal nerve activity (ARNA), the ipsilateral renal pelvic release of substance P (SP) and the contralateral urinary sodium excretion in Wistar-Kyoto rats (WKy). However, spontaneously hypertensive rats (SHR) present an impaired renorenal reflex activity associated, partly, with a peripheral defect at the level of the sensory receptors in the renal pelvis. Furthermore, the renal pelvic administration of SP failed to increase ARNA in most of SHR at concentrations that produced marked increases in WKy. Since we have assessed the expression and localization of NK1 receptor (NK1R), SP and calcitonin gene-related peptide (CGRP) in different dorsal root ganglia (DRG) cell subtypes and renal pelvis of 7- and 14-week-old SHR. The results of this study show increased SP and CGRP expression in the dorsal ganglia root cells of SHR compared to WKy rats. Additionally, there was a progressive, significant, age-dependent, decrease in NK1R expression on the membrane surface in SHR DRG cells and in the renal pelvis. In conclusion, the results of the present study suggest that the impaired activation of renal sensory neurons in SHR may be related to changes in the expression of neuropeptides and/or to a decreased presence of NK1R in DRG cells. Such abnormalities could contribute to the enhanced sodium retention and elevation of blood pressure seen in SHR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 138, Issue 1, 29 July 2005, Pages 35-44
Journal: Molecular Brain Research - Volume 138, Issue 1, 29 July 2005, Pages 35-44
نویسندگان
PatrÃcia Aline Boer, Mirian Ueno, Jenifer S.M. Sant'Ana, Mário J.A. Saad, José Antonio Rocha Gontijo,