کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410675 | 1613319 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of aging on different C-terminal splice forms of the ζ1(NR1) subunit of the N-methyl-d-aspartate receptor in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Changes in NMDA receptors in the prefrontal/frontal cortex and hippocampus of C57BL/6 mice during aging show a relationship to declines in spatial learning. The present study was designed to determine whether aging influences the mRNA expression of different splice forms of the ζ1 subunit of the NMDA receptor. We examined the mRNA of 4 C-terminal splice forms with the use of in situ hybridization. The ζ1-1 splice form (+C1 and +C2 cassettes) overall showed a maintenance of mRNA density from 3 to 10 months of age, followed by a significant decline by 26 months of age. In contrast, the mRNA for the ζ1-3 splice form [+C1 and +C2â²(âC2)] showed significant declines between 3- and 10-month-old mice. These declines were maintained in the old mice. The ζ1-2 splice form (âC1 and +C2) showed a near-significant decrease in expression during aging across all brain regions. The ζ1-4 subunit mRNA [âC1 and +C2â² (âC2)] showed no significant changes with increased age. These results indicate that there is a differential effect of aging on different splice variants of the ζ1 subunit of the NMDA receptor and those that are affected show a different temporal pattern of aging. This heterogeneity has implications for producing imbalances in the modulation of the remaining receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 135, Issues 1â2, 27 April 2005, Pages 141-149
Journal: Molecular Brain Research - Volume 135, Issues 1â2, 27 April 2005, Pages 141-149
نویسندگان
Kathy R. Magnusson, Ling Bai, Xue Zhao,