کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9410823 1291276 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
α-1-Antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA)
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
α-1-Antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA)
چکیده انگلیسی
We investigated three genotypes (AA, AT, and TT) produced by signal peptide polymorphism of the α-1-antichymotrypsin (ACT) gene in 105 patients with multiple system atrophy (MSA) and age-matched controls. The frequency of ACT-AA genotype was significantly higher in patients with MSA (20.0%) than in controls (10.5%). The onset of MSA was significantly earlier and the disease progressed significantly faster in patients with ACT-AA genotype than in those with non-ACT-AA genotypes. The ACT concentration in cerebrospinal fluid was increased in patients with ACT-AA. To our knowledge, this is the first study to show that the ACT-AA genotype is a risk factor and modulating factor for MSA. Our findings suggest the involvement of ACT-relating inflammatory process in the pathogenesis of MSA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 138, Issue 2, 18 August 2005, Pages 178-181
نویسندگان
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