کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410823 | 1291276 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α-1-Antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
We investigated three genotypes (AA, AT, and TT) produced by signal peptide polymorphism of the α-1-antichymotrypsin (ACT) gene in 105 patients with multiple system atrophy (MSA) and age-matched controls. The frequency of ACT-AA genotype was significantly higher in patients with MSA (20.0%) than in controls (10.5%). The onset of MSA was significantly earlier and the disease progressed significantly faster in patients with ACT-AA genotype than in those with non-ACT-AA genotypes. The ACT concentration in cerebrospinal fluid was increased in patients with ACT-AA. To our knowledge, this is the first study to show that the ACT-AA genotype is a risk factor and modulating factor for MSA. Our findings suggest the involvement of ACT-relating inflammatory process in the pathogenesis of MSA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 138, Issue 2, 18 August 2005, Pages 178-181
Journal: Molecular Brain Research - Volume 138, Issue 2, 18 August 2005, Pages 178-181
نویسندگان
Yoshiko Furiya, Makito Hirano, Norio Kurumatani, Takuya Nakamuro, Ryusuke Matsumura, Naonobu Futamura, Satoshi Ueno,