کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410859 | 1291277 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CAA insertion polymorphism in the 3â²UTR of Nogo gene on 2p14 is not associated with schizophrenia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CAA insertion polymorphism in the 3â²UTR of Nogo gene on 2p14 is not associated with schizophrenia CAA insertion polymorphism in the 3â²UTR of Nogo gene on 2p14 is not associated with schizophrenia](/preview/png/9410859.png)
چکیده انگلیسی
The Nogo gene was putatively implicated in schizophrenia based on gene expression and genetic association data. In this study, we attempt to replicate the possible association of the CAA insertion and a nearby TATC deletion with schizophrenia in 204 complete and incomplete triads and in a sample of 462 unrelated cases and 153 controls, all of Caucasian origin. Our genotyping results indicated that neither the trinucleotide insertion polymorphism (CAAins; 43.4% vs. 41.8%, p>0.5) nor the polymorphism-TATC deletion (TATCdel; 49.8% vs. 49.3%, p>0.1) allele frequency is significantly different in patients compared to controls. The homozygous CAAins frequency is not significantly different between patients and controls either (18.0% vs. 15.0%, Ï2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 133, Issue 1, 5 January 2005, Pages 153-156
Journal: Molecular Brain Research - Volume 133, Issue 1, 5 January 2005, Pages 153-156
نویسندگان
Lan Xiong, Guy A. Rouleau, Lynn E. DeLisi, Judith St-Onge, Robert Najafee, Jean-Baptiste Rivière, Chawki Benkelfat, Karim Tabbane, Ferid Fathalli, Zoltan Danics, Alain Labelle, Samarthji Lal, Ridha Joober,