کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415804 | 1614323 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons
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کلمات کلیدی
dorsal root ganglion - گانگلیون ریشه پشتیanandamide - آناندامیدTetrodotoxin-sensitive - تترودوتوکسین حساسNa+ current - جریان + Na +Excitable membranes and synaptic transmission - غشاء جذاب و انتقال سیناپسیTetrodotoxin-resistant - مقاوم در برابر تترودوتوکسینCannabinoid - کانابینوئیدsodium channels - کانال های سدیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Anandamide, the ethanolamide of arachidonic acid, is an endogenous cannabinoid. It is an agonist at CB1 and CB2 cannabinoid receptors as well as the vanilloid receptor, VR1. It is analgesic in inflammatory and neuropathic pain. Both central and peripheral mechanisms are considered to participate in its analgesia. Primary sensory neurons express Na+ currents that are involved in the pathogenesis of pain. We examined the effect of anandamide on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ currents in rat dorsal root ganglion neurons. Anandamide inhibited both Na+ currents in a concentration-dependent manner. At a membrane potential of â80 mV, the current inhibition was greater in TTX-S than TTX-R currents (Kd; 5.4 μM vs. 38.4 μM). The activation and inactivation became faster in TTX-R current but not in TTX-S current. Anandamide did not alter the activation voltage in either type of current. It, however, produced a hyperpolarizing shift of the steady-state inactivation voltage in both types of currents. The maximum availability at a large negative potential was not reduced by anandamide. Thus, anandamide seems to affect inactivated Na+ channels rather than resting channels. The inhibition of Na+ currents was not reversed by AM 251 (a CB1 antagonist), AM 630 (a CB2 antagonist) or capsazepine (a VR1 antagonist), suggestive of a direct action of anandamide on Na+ channels. The inhibition of Na+ currents in sensory neurons may contribute to the anandamide analgesia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1062, Issues 1â2, 16 November 2005, Pages 39-47
Journal: Brain Research - Volume 1062, Issues 1â2, 16 November 2005, Pages 39-47
نویسندگان
Hong Im Kim, Tae Hoon Kim, Yong Kyoo Shin, Chung Soo Lee, Mijung Park, Jin-Ho Song,