کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415815 | 1614323 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Neurosteroidsedative effect - اثر آرام بخشDisorders of the nervous system - اختلالات سیستم عصبیallopregnanolone - الوپرگنانولونAudiogenic seizure - تشنج شنواییpregnenolone sulfate - سولفات حاملنولونEpilepsy: anti-convulsant drugs - صرع: داروهای ضد تشنجAnticonvulsant activity - فعالیت ضد انعقادیNicotine - نیکوتین Hippocampus - هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine](/preview/png/9415815.png)
چکیده انگلیسی
Allopregnanolone (AlloP), GABAA positive modulator, has efficacy as anticonvulsant. In contrast, nicotine and pregnenolone sulfate (PregS) act as potent convulsants. The present study aims to evaluate whether a promnesic dose of PregS and/or an anxiolytic dose of AlloP administered in the hippocampus can affect the audiogenic seizures induced by nicotine administration. Rats were assigned at random to six groups that received two consecutive intrahippocampal (dorsal CA1) injections once a week during three consecutive weeks. First injection: nicotine (4.6 μg, 20 mM) or saline, second injection: PregS (5 ng, 24 μM), AlloP (0.2 μg, 1.26 μM) or saline. After the last injections, locomotor activity and audiogenic seizures were tested. AlloP decreased the horizontal and vertical activity, suggesting sedative effects. Nicotine induced behavioral convulsions and AlloP acted as an anticonvulsant. AlloP reversed the seizures induced by nicotine and decreased the audiogenic convulsions in comparison with the controls. PregS also reversed the nicotine-induced audiogenic seizures in the nicotine group but not in the control group. These results suggest that anticonvulsive effects of AlloP and PregS are mediated by different action mechanisms such as GABAA positive modulation, or negative modulatory action on neural nicotinic acetylcholine receptors. Even though several brain structures could be involved, these results highlight the important role played by hippocampal cholinergic and GABAergic activities, as well as neurosteroids, especially AlloP, in preventing convulsive behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1062, Issues 1â2, 16 November 2005, Pages 144-150
Journal: Brain Research - Volume 1062, Issues 1â2, 16 November 2005, Pages 144-150
نویسندگان
Elena Martin-Garcia, Marc Pallares,