کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415856 | 1292946 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TGFα and AVP in the mouse suprachiasmatic nucleus: Anatomical relationship and daily profiles
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: TGFα and AVP in the mouse suprachiasmatic nucleus: Anatomical relationship and daily profiles TGFα and AVP in the mouse suprachiasmatic nucleus: Anatomical relationship and daily profiles](/preview/png/9415856.png)
چکیده انگلیسی
Daily rhythms in behavior and physiology are under control of the suprachiasmatic nucleus (SCN), the main mammalian circadian pacemaker located in the hypothalamus. The SCN communicates with the rest of the brain via various output systems. The aim of the present study was to determine the neuroanatomical and temporal relationship between two output systems, arginine-vasopressin (AVP) and transforming growth factor α (TGFα), in the mouse SCN. TGFα-positive cells were found throughout the SCN, but more abundantly in the core than the shell area, while AVP was predominantly found in the shell. Fluorescent double labeling revealed a total lack of co-expression for the two proteins in SCN cells. The circadian profile, studied by way of optical density in immunostaining at 3 h intervals, showed peak values for AVP shortly after the LD transitions. Immunoreactivity for TGFα was highly variable, especially at time points before the LD transitions. In addition, strong lateralization in TGFα immunostaining in the SCN was found in some individuals. Daily fluctuations in the paraventricular nucleus were absent for TGFα, and only weakly present for AVP. The main conclusion derived from this study is that these two output systems of the biological clock are anatomically separated with different daily profiles in expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1054, Issue 2, 30 August 2005, Pages 159-166
Journal: Brain Research - Volume 1054, Issue 2, 30 August 2005, Pages 159-166
نویسندگان
E.A. Van der Zee, V. Roman, O. ten Brinke, P. Meerlo,