کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9415962 1292951 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain
چکیده انگلیسی
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) and trkB both have a role in plasticity following brain insults and exercise increases BDNF and trkB mRNA levels in the normal brain. We attempted to determine whether treadmill exercise improves motor function following experimental cerebral ischemia, and whether motor outcome is associated with BDNF and trkB expression. We subjected adult male Sprague-Dawley rats to a permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. In the exercise group, improvements in the motor behavior index were found and BDNF and trkB proteins in contralateral hemisphere were increased. This study suggests that after permanent brain ischemia, exercise improves motor performance and elevates BDNF and trkB proteins in the contralateral hemisphere.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1052, Issue 1, 2 August 2005, Pages 16-21
نویسندگان
, , , , , , , , ,