کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416733 | 1292981 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The expression of calcium/calmodulin-dependent protein kinase II-α in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Alzheimer's disease (AD) is characterized pathologically by selective neuronal loss and by the formation of neurofibrillary tangles (NFTs) and senile plaques (SPs). Since calcium/calmodulin-dependent protein kinase II-α (CaMKII-α), one of the most abundant kinases in the brain, is involved in the phosphorylation of tau and amyloid precursor protein (APP), we examined the expression of CaMKII-α and its relationships with the neuropathology in the hippocampus of AD patients using immunohistochemistry and double-labeling immunofluorescence methods. The results showed that CaMKII-α containing neurons were selectively lost in the CA1 subfield of AD hippocampus and accompanied with enhanced immunoreactivity in the remaining neurons. About 33% hyperphosphorylated tau-containing neurons labeled by monoclonal antibody AT-8 were also immunoreactive for CaMKII-α. Moreover, we found for the first time that the immunoreactivity of CaMKII-α was largely deposited in the SPs of the AD hippocampus. The pattern of the co-localization of CaMKII-α with beta amyloid depended on the type of SPs. Since the co-localization of CaMKII-α with hyperphosphorylated tau is relatively rare, we concluded that CaMKII-α may be related with β-amyloid more closely than being involved in tau hyperphosphorylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1031, Issue 1, 7 January 2005, Pages 101-108
Journal: Brain Research - Volume 1031, Issue 1, 7 January 2005, Pages 101-108
نویسندگان
Yue-Ju Wang, Gui-Hai Chen, Xiang-You Hu, Ya-Ping Lu, Jiang-Ning Zhou, Rong-Yu Liu,