کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9416879 1292987 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mice lacking d-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Mice lacking d-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801
چکیده انگلیسی
The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO−/− mice lacking d-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the d-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated d-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1033, Issue 2, 8 February 2005, Pages 210-215
نویسندگان
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