کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9423160 | 1294778 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation
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کلمات کلیدی
apolipoprotein E - آپولیپوپروتئین EDisorders of the nervous system - اختلالات سیستم عصبیNeuroinflammation - التهاب عصبیIschemia - ایسکمیAlzheimer's disease - بیماری آلزایمرDegenerative disease: Alzheimer's—miscellaneous - بیماری تخریب پذیر: آلزایمر- متفرقهNeurodegeneration - تولید نوروژنیکMicroglia - میکروگلیاها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation](/preview/png/9423160.png)
چکیده انگلیسی
Progressive memory impairment, β-amyloid (Aβ) plaques associated with local inflammation, neurofibrillary tangles, and loss of neurons in selective brain areas are hallmarks of Alzheimer's disease (AD). Although β-amyloid precursor protein (APP) and Aβ have a central role in the etiology of AD, it is not clear which forms of APP or Aβ are responsible for the neuronal vulnerability in AD brain. Brain ischemia, another cause of dementia in the elderly, has recently been recognized to contribute to the pathogenesis of AD and individuals with severe cognitive decline and possibly underlying AD are at increased risk for ischemic events in the brain. Moreover, the ε4 allele of apolipoprotein E (ApoE) is a risk factor for both AD and poor outcome following brain ischemia and hemorrhage. Several factors and molecular mechanisms that lower the threshold of neuronal death in models of AD have recently been described. Among these neuroinflammation seems to play an important role. The development and maturation of both AD neuropathology and ischemic lesions in the central nervous system are characterized by activation of glial cells and upregulation of inflammatory mediators. Indeed, anti-inflammatory approaches have proven to be beneficial in the prevention and treatment of AD-like neuropathology and ischemic injuries in vivo. This review summarizes some of the findings suggesting that neuronal overexpression of human APP renders the brain more vulnerable to ischemic injury and describes the factors that are involved in increased neuronal susceptibility to ischemic stroke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Reviews - Volume 48, Issue 2, April 2005, Pages 240-250
Journal: Brain Research Reviews - Volume 48, Issue 2, April 2005, Pages 240-250
نویسندگان
Milla Koistinaho, Jari Koistinaho,