کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9425352 1295863 2005 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopamine prevents muscarinic-induced decrease of glutamate release in the auditory cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Dopamine prevents muscarinic-induced decrease of glutamate release in the auditory cortex
چکیده انگلیسی
Acetylcholine and dopamine are simultaneously released in the cortex at the occurrence of novel stimuli. In addition to a series of excitatory effects, acetylcholine decreases the release of glutamate acting on presynaptic muscarinic receptors. By recording evoked excitatory postsynaptic currents in layers II/III neurons of the auditory cortex, we found that activation of muscarinic receptors by oxotremorine reduces the amplitude of glutamatergic current (Aoxo/Actr=0.53±0.17) in the absence but not in the presence of dopamine (Aoxo/Actr=0.89±0.12 in 20μM dopamine). These data suggested that an excessive sensitivity to dopamine, such as postulated in schizophrenia, could prevent the decrease of glutamate release associated with the activation of cholinergic corticopetal nuclei. Thus, a possible mechanism of action of antipsychotic drugs could be through a depression of the glutamatergic signal in the auditory cortex. We tested the capability of haloperidol, clozapine and lamotrigine to affect glutamatergic synaptic currents and their muscarinic modulation. We found that antipsychotics not only work as dopamine receptor antagonists in re-establishing muscarinic modulation, but also directly depress glutamatergic currents. These results suggest that presynaptic modulation of glutamate release can account for a dual route of action of antipsychotic drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 4, 2005, Pages 1153-1165
نویسندگان
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