کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425425 | 1295872 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regional hippocampal alteration associated with cognitive deficit following experimental brain injury: A systems, network and cellular evaluation
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کلمات کلیدی
MWME-STBImIPSCDHKeIPSCsasfHECfEPSPAP5TTXaCSFSSF6-Cyano-7-nitroquinoxaline-2,3-dione - 6-Cyano-7-nitroquinoxaline-2،3-dioneEPSP - epspiI/O - I / OFPI - REITTraumatic brain injury - آسیب تروماتیک مغزFluid percussion injury - آسیب سیاتیکhead injury - آسیب به سرStereology - استریولوژیPopulation spike - افزایش جمعیتtetrodotoxin - تترو دوتوکسین long-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP miniature inhibitory postsynaptic currents - جریان ممانعت کننده پسینپتیکdihydrokainic acid - دی هیدروکینیک اسیدCNQX - سیانکیوایکسBMI - شاخص توده بدنیdentate gyrus - شکنج دندانه دارCoefficient of Variation - ضریب تغییرcoefficient of error - ضریب خطاMorris water maze - ماز آب آب موریسartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیbicuculline methiodide - متیکویدید bicucullinePerforant path - مسیر پرفورنتSeries resistance - مقاومت سریevoked inhibitory postsynaptic current - موجب شده است که جریان پستانی پات را مهار کندHippocampus - هیپوکامپ input/output - ورودی خروجیexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزField excitatory postsynaptic potential - پتانسیل پستنیپتیک مزمن تحریک پذیرarea sampling fraction - کسر نمونه برداری از منطقهGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cognitive deficits persist in patients who survive traumatic brain injury (TBI). Lateral fluid percussion brain injury in the mouse, a model of human TBI, results in hippocampal-dependent cognitive impairment, similar to retrograde amnesia often associated with TBI. To identify potential substrates of the cognitive impairment, we evaluated regional neuronal loss, regional hippocampal excitability and inhibitory synaptic transmission. Design-based stereology demonstrated an approximate 40% loss of neurons through all subregions of the hippocampus following injury compared with sham. Input/output curves recorded in slices of injured brain demonstrated increased net synaptic efficacy in the dentate gyrus in concert with decreased net synaptic efficacy and excitatory postsynaptic potential-spike relationship in area CA1 compared with sham slices. Pharmacological agents modulating inhibitory transmission partially restored regional injury-induced alterations in net synaptic efficacy. Both evoked and spontaneous miniature inhibitory postsynaptic currents (mIPSCs) recorded in surviving dentate granule neurons were smaller and less frequent in injured brains than in uninjured brains. Conversely, both evoked and spontaneous mIPSCs recorded in surviving area CA1 pyramidal neurons were larger in injured brains than in uninjured brains. Together, these alterations suggest that regional hippocampal function is altered in the injured brain. This study demonstrates for the first time that brain injury selectively disrupts hippocampal function by causing uniform neuronal loss, inhibitory synaptic dysfunction, and regional, but opposing, shifts in circuit excitability. These changes may contribute to the cognitive impairments that result from brain injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 133, Issue 1, 2005, Pages 1-15
Journal: Neuroscience - Volume 133, Issue 1, 2005, Pages 1-15
نویسندگان
B.M. Witgen, J. Lifshitz, M.L. Smith, E. Schwarzbach, S.-L. Liang, M.S. Grady, A.S. Cohen,