کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425554 | 1295878 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
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کلمات کلیدی
PBSArcuate nucleiSupraoptic nucleiVMHBSTLOVLTLPBNNTSDRNPAGDMNMEASFOLSVCeA - CEAMnR - MNRmedial amygdala - آمدیگدال medialCentral amygdala - آمیگدالای مرکزیorganum vasculosum of the lamina terminalis - ارگانواسکوئوزوم ترمینال لامیناSCH - اس اسFed state - دولت فدرالSerotonin - سروتونینarea postrema - طبقه آخرSubfornical organ - عضو زیربنیکیSON - فرزند پسرFos-ir - فوزیArc - قوسlocus coeruleus - لوکوس سیرولئوسPeriaqueductal gray matter - ماده خاکستری پرایاکوداکتPVN - مالیات بر ارزش افزودهPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریserotonin reuptake inhibitors - مهار کننده های بازجذب سروتونینnucleus of the solitary tract - هسته دستگاه انفرادیmedian raphe nucleus - هسته رافائل مرکزیDorsal raphe nuclei - هسته رافه خالصSuprachiasmatic nuclei - هسته های SuprachiasmaticParaventricular nuclei - هسته پروژسترونlateral hypothalamus - هیپوتالاموس جانبیVentromedial hypothalamus - هیپوتالاموس ونتومدیال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats](/preview/png/9425554.png)
چکیده انگلیسی
In the present study we investigated the effect of acute fluoxetine administration on the expression of c-Fos in the rat brain under two different metabolic conditions: fed and fasting states. Wistar male rats, weighing 220±30g, received i.p. injections of saline solution or fluoxetine (10mg/kg), and were killed 2 h later. The brains were removed after transcardiac perfusion with phosphate-buffered saline followed by paraformaldehyde, and were then processed for immunohistochemistry. Fos-like immunoreactivity was quantified by a computerized system. Fasted animals faced an 18-h suppression of food intake, while fed groups were submitted to an initial 14-h period of fast followed by a 4-h period in which food was freely available. Both in fasting and fed states, fluoxetine-treated animals presented a significant increase in c-Fos expression in hypothalamic areas, limbic structures, circumventricular areas, and in mesencephalic and rhomboencephalic regions, as compared with saline-treated controls. The quantitative comparison of data obtained from fasted and fed animals showed that fasted rats treated with fluoxetine presented a higher c-Fos expression in the ventromedial hypothalamus and the paraventricular nuclei compared with the fed group, while in fluoxetine-treated fed rats c-Fos expression was higher in the arcuate nuclei, medial amygdala, locus coeruleus and dorsal raphe nuclei, as compared with fasted, fluoxetine-treated animals. These data indicate that the metabolic condition of the animals significantly modifies fluoxetine-induced brain c-Fos expression, suggesting that visceral and behavioral fluoxetine effects may be influenced by the metabolic state of the individual.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 1, 2005, Pages 327-334
Journal: Neuroscience - Volume 134, Issue 1, 2005, Pages 327-334
نویسندگان
I.C. Fraga, J.B. Fregoneze, F.L.Q. Carvalho, K.B. Dantas, C.S. Azevedo, C.B. Pinho, E. de Castro e Silva,