Peroxisome Proliferator-Activated Receptors (PPARs) and related transcription factors in differentiating astrocyte cultures

In conclusion, our results, reporting modifications of PPARs, RXRs, C/EBPs and β-catenin during culture time, strongly suggest the involvement of these transcription factors in astrocyte differentiation. Specifically, β-catenin translocation from the nucleus to plasma membrane, together with PPARβ/δ decrease and C/EBPα increase, could be related to decreased proliferation at confluence, while PPARα and γ and all C/EBPs could participate in differentiation processes, such as glycogenesis and lipidogenesis.