کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425795 | 1295893 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurotensin modulates synaptic transmission in the nucleus of the solitary tract of the rat
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کلمات کلیدی
sIPSCspost-synaptic currentsN-methyl-d-aspartate acidNTS1DepolarizationsEPSCDNQXAP5aCSFNMDANTSTTXD(−)-2-amino-5-phosphonopentanoic acid - D (-) - 2-amino-5-phosphonopentanoic acidElectrophysiology - الکتروفیزیولوژیtetrodotoxin - تترو دوتوکسین excitability - تحریک پذیریSlice - تکهspontaneous excitatory postsynaptic currents - جریان های پسینپتیک هیجان انگیز خودبهخودیSpontaneous inhibitory postsynaptic currents - جریانهای پسینپتیک مهار کننده خود به خودیSolitary tract - دستگاه تناسلیAHP - فرایند تحلیل سلسلهمراتبیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیneurotensin - نوروتنسینnucleus tractus solitarius - هسته دستگاه انفرادیafter-hyperpolarization - پس از hyperpolarization
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neurotensin modulates synaptic transmission in the nucleus of the solitary tract of the rat Neurotensin modulates synaptic transmission in the nucleus of the solitary tract of the rat](/preview/png/9425795.png)
چکیده انگلیسی
Whole-cell patch clamp recordings were made from neurons of the rat subpostremal region of the nucleus tractus solitarius (NTS) in transverse brainstem slices. Neurotensin (NT) enhanced the firing rate of action potentials from 0.8±0.4 Hz in control to 1.9±1.3 Hz (n=9) and increased their decay time. The peak amplitude of the after-hyperpolarization was decreased by 34±5% (n=9). These effects were associated with a depolarization of 4±1 mV (n=10) in the resting membrane potential and an increase in the input resistance (from 768±220 MΩ to 986±220 MΩ; n=5) and were compensated by manually hyperpolarizing the cell to control values. In voltage clamp experiments NT decreased an outward current (from 488±161 to 340±96 pA at +40 mV; n=5) which reversed near the potassium equilibrium potential. In addition, NT increased the frequency of both excitatory and inhibitory spontaneous synaptic currents, an effect blocked by tetrodotoxin, and did not change the evoked excitatory or inhibitory postsynaptic currents. The selective NTR1 receptor antagonist SR48692 reversibly blocked the effects of NT on both action potentials and spontaneous synaptic currents. Our results suggest that NTR1 receptors can modulate post-synaptic responses in neurons of the subpostremal NTS by increasing cell excitability as a result of blockade of a potassium conductance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 130, Issue 2, 2005, Pages 309-315
Journal: Neuroscience - Volume 130, Issue 2, 2005, Pages 309-315
نویسندگان
W.N. Ogawa, V. Baptista, J.F. Aguiar, W.A. Varanda,