کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425797 | 1295893 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
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کلمات کلیدی
ECLDMEMSDSPVDFGFAPacyl-CoA oxidaseAOXPPARRXRTBSTDAPI4′,6-diamino-2-phenylindole - 4 '، 6-دیامینو-2-فنیلینولBSA - BSADulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده Dulbeccobovine serum albumin - آلبومین سرم گاوOligodendrocyte - الیگودندروسیتNeuronal maturation - بلوغ عصبیenhanced chemiluminescence - بهبود شیمیایی لومنGene expression - بیان ژنDifferentiation - تفکیکminimum essential medium - حداقل حداقل مورد نیازDIV - دیوdays in vitro - روز in vitrosodium dodecyl sulfate - سدیم دودسیل سولفاتTranscription factors - عوامل رونویسیMEM - مامانneurofilament - نوروفیلامنتpolyvinyldifluoride - پلی وینیلدفلوئوریدTarget genes - ژنهای هدفRetinoic acid receptor - گیرنده اسید رتینوئیکperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Neuronal differentiation is a complex process involving the sequential expression of several factors. The important role of lipid molecules in brain development is well known. Many fatty acid cell signaling activities are mediated by peroxisome proliferator-activated receptors (PPARs). PPARs are ligand-activated transcription factors belonging to the steroid, thyroid and retinoid nuclear receptor superfamily. They are activated by fatty acids and their derivatives. Different isotypes of PPARs (α, β/δ and γ) have distinct physiological functions depending on their different ligand activation profiles and tissue distribution. PPARs have been involved in neural cell differentiation and death as well as in inflammation and neurodegeneration. Although PPARs have been described in neurons by in situ studies, the presence and possible modulation of these receptors during neuronal differentiation has not been explored yet. In this study we analyzed the expression of PPARs and of their heterodimeric partners, RXRs, in embryonic rat cortical neurons during their in vitro maturation. Our results demonstrate the presence of PPARs α, β/δ and γ and of RXRs β and γ. PPARα, β/δ and γ are differentially modulated during culture time suggesting that they may be involved in neuronal maturation. In particular, we point toward the PPARβ/δ isotype as a key factor in neuronal differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 130, Issue 2, 2005, Pages 325-337
Journal: Neuroscience - Volume 130, Issue 2, 2005, Pages 325-337
نویسندگان
A. Cimini, E. Benedetti, L. Cristiano, P. Sebastiani, M.A. D'amico, B. D'angelo, S. Di Loreto,