کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425933 | 1295899 | 2005 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: Implications for the circadian control of behavioural state
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کلمات کلیدی
DABsPVZHDCVAChTSCNBDAREMHDBMPANPYDMHCTBAminergic - آمینیرژیکhorizontal limb of the diagonal band of Broca - اندام افقی از گروه مورب BrocaOrexin/hypocretin - اورکسین / هیپوکتینimmunoreactive - ایمنی فعالImmunohistochemistry - ایمونوهیستوشیمیbiotinylated dextran-amine - بیترهید شده دکستران آمینLight–dark - تیره روشن یا کمرنگ و پررنگtyrosine hydroxylase - تیروزین هیدروکسیلازvesicular acetylcholine transporter - حمل کننده استیل کولین vesiculardiaminobenzidine - دیامینو بنزیدینPosterior - عقبanterior - قدامیSubparaventricular zone - منطقه فرعی دریاییPosterior hypothalamic area - منطقه هیپوتالاموس پشتیmedial preoptic area - منطقه پیشوپتیک مدیاdorsomedial hypothalamic nucleus - هسته هیپوتالاموس dorsomedialSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکHistidine Decarboxylase - هیستیدین دکربوکسیلازcholera toxin B subunit - کلسترول توکسین B واحدCholinergic - کولینرژیکNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The circadian clock housed in the suprachiasmatic nucleus (SCN) controls various circadian rhythms including daily sleep-wake cycles. Using dual tract-tracing, we recently showed that the medial preoptic area (MPA), subparaventricular zone (SPVZ) and dorsomedial hypothalamic nucleus (DMH) are well positioned to relay SCN output to two key sleep-promoting nuclei, namely, the ventrolateral and median preoptic nuclei. The present study examined the possibility that these three nuclei may link the SCN with wake-regulatory neuronal groups. Biotinylated dextran-amine with or without cholera toxin B subunit was injected into selected main targets of SCN efferents; the retrograde labeling in the SCN was previously analyzed. Here, anterograde labeling was analyzed in immunohistochemically identified cholinergic, orexin/hypocretin-containing and aminergic cell groups. Tracer injections into the MPA, SPVZ and DMH resulted in moderate to dense anterograde labeling of varicose fibers in the orexin field and the tuberomammillary nucleus. The locus coeruleus, particularly the dendritic field, contained moderate anterograde labeling from the MPA and DMH. The ventral tegmental area, dorsal raphe nucleus, and laterodorsal tegmental nucleus all showed moderate anterograde labeling from the DMH. The substantia innominata showed moderate anterograde labeling from the MPA. These results suggest that the MPA, SPVZ and DMH are possible relay nuclei for indirect SCN projections not only to sleep-promoting preoptic nuclei as previously shown, but also to wake-regulatory cell groups throughout the brain. In the absence of major direct SCN projections to most of these sleep/wake-regulatory regions, indirect neuronal pathways probably play an important role in the circadian control of sleep-wake cycles and other physiological functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 130, Issue 1, 2005, Pages 165-183
Journal: Neuroscience - Volume 130, Issue 1, 2005, Pages 165-183
نویسندگان
S. Deurveilher, K. Semba,