کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426418 | 1295920 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subcellular distribution and plasticity of neurokinin-1 receptors in the rat substantia nigra and ventral tegmental area
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کلمات کلیدی
NIDANIHPPINK1SNRiAsVTASubstantia nigra pars reticulataApomorphine - آپومرفینSchizophrenia - اسکیزوفرنی یا شیزوفرنیphosphate buffer - بافر فسفاتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancesubstantia nigra - توده سیاهtyrosine hydroxylase - تیروزین هیدروکسیلازDopamine - دوپامینDopaminergic - دوپامینرژیکNational Institutes of Health - مؤسسات ملی بهداشتSubstance P - ماده PPrepulse inhibition - مهار پیش قاعدگیNational Institute of Mental Health - موسسه ملی سلامت روانventral tegmental area - ناحیه تگمنتوم شکمیneurokinin-1 - نورو کینین-1NIMH - نیمهacoustic startle - هیجان صوتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Subcellular distribution and plasticity of neurokinin-1 receptors in the rat substantia nigra and ventral tegmental area Subcellular distribution and plasticity of neurokinin-1 receptors in the rat substantia nigra and ventral tegmental area](/preview/png/9426418.png)
چکیده انگلیسی
Neurokinin-1 receptors show activity-dependent changes in their surface distributions that are critical in spinal pain mechanisms, and also may play an important role in the motor and affective behaviors influenced by dopaminergic projections from the substantia nigra and ventral tegmental area. To determine the relevant sites for neurokinin-1 receptor activation in these midbrain regions, we examined the electron microscopic immunolabeling of neurokinin-1 receptors and the dopamine-synthesizing enzyme, tyrosine hydroxylase in normal rats. We also examined whether neurokinin-1 receptor distributions in one or both regions are affected by (1) startle-evoking intense auditory stimulation or (2) acute administration of apomorphine, a dopamine D1/D2 agonist that enhances startle while paradoxically reducing the prepulse inhibition produced by low intensity conditioning stimuli in rat models of schizophrenia. In each region, neurokinin-1 immunogold was located on the plasma membrane and endomembranes of somatodendritic profiles with or without tyrosine hydroxylase. As compared with controls, animals receiving intense auditory stimulation either alone or together with smaller low intensity prepulses showed a significant increase in neurokinin-1-plasmalemmal labeling in non-dopaminergic dendrites of both regions, and a reduction in this labeling in dopaminergic dendrites of the ventral tegmental area. Both effects were diminished following apomorphine administration. In absence of the intense auditory stimulation, however, apomorphine increased neurokinin-1-immunogold particles on the plasma membrane of the non-dopaminergic dendrites exclusively in the substantia nigra. Our results are the first to show that neurokinin-1 receptors have plasmalemmal distributions in dopaminergic and non-dopaminergic neurons that can be differentially modified by startle-evoking auditory stimulation. They suggest that while apomorphine can independently affect neurokinin-1 receptor trafficking in substantia nigra motor circuits, its effects on neurokinin-1 receptor distributions in the ventral tegmental area are exclusively dependent on sensory activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 135, Issue 4, 2005, Pages 1309-1323
Journal: Neuroscience - Volume 135, Issue 4, 2005, Pages 1309-1323
نویسندگان
A. Lessard, V.M. Pickel,