کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426592 | 1295927 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Signaling pathways of interleukin-1 actions in the brain: Anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1β
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کلمات کلیدی
IL-1βSSPphosphorylated ERK1/2OVLTARHCVOIB4IL-1RINeuNCRFSFOGFAPSSSJnkCHPc-Jun N-terminal kinase - C-Jun N-terminal kinaseMPO - DFOERK1/2 - ERK1 / 2MAPK - MAPKNFκB - NFKBp-ERK1/2 - P-ERK1 / 2vascular organ of the lamina terminalis - ارگان عروقی ترمینال لامیناinflammation - التهاب( توروم) isolectin B4 - ایزوکتین B4Interleukin-1β - اینترلوکین-1βphosphate buffer - بافر فسفاتPir - بیش از حدBBB - سد خونی مغزیarea postrema - طبقه آخرcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینSubfornical organ - عضو زیربنیکیCircumventricular organ - عضو پیوند قرنیهnuclear factor kappa B - فاکتور هسته ای کاپا BSON - فرزند پسرBlood-brain barrier - مانع خون مغزیBrain - مغزmedial preoptic area - منطقه پیشوپتیک مدیاNeuroanatomy - نوروآناتومی یا کالبدشناسی اعصابSupraoptic nucleus - هسته Supraopticarcuate nucleus of the hypothalamus - هسته قوس هیپوتالاموسneuronal nuclei - هسته های نورونیmedian preoptic nucleus - هسته پیشوپتیک مدیاستGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenChoroid plexus - پیوند کوئیدextracellular signal-regulated kinase 1 and 2 - کیناز 1 و 2 تنظیم شده با سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Interleukin-1β is released at the periphery during infection and acts on the nervous system to induce fever, neuroendocrine activation, and behavioral changes. These effects are mediated by brain type I IL-1 receptors. In vitro studies have shown the ability of interleukin-1β to activate mitogen-activated protein kinase signaling pathways including p38, c-Jun N-terminal kinase and extracellular signal-regulated protein kinase 1 and 2 (ERK1/2). In contrast to other mitogen-activated protein kinases, little is known about ERK1/2 activation in the rat brain in response to interleukin-1β. The aim of the present study was therefore to investigate spatial and temporal activation of ERK1/2 in the rat brain after peripheral administration of interleukin-1β using immunohistochemistry to detect the phosphorylated form of the kinase. In non-stimulated conditions, phosphorylated ERK1/2 immunoreactivity was observed in neurons throughout the brain. Administration of interleukin-1β (60μg/kg, i.p.) induced the phosphorylation of ERK1/2 in areas at the interface between brain and blood or cerebrospinal fluid: meninges, circumventricular organs, endothelial like cells of the blood vessels, and in brain nuclei involved in behavioral depression, fever and neuroendocrine activation: paraventricular nucleus of the hypothalamus, supraoptic nucleus, central amygdala and arcuate nucleus. Double labeling of phosphorylated ERK1/2 and cell markers revealed the expression of phosphorylated ERK1/2 in neurons, astrocytes and microglia. Since phosphorylated ERK1/2 was found in structures in which type I IL-1 receptor has already been identified as well as in structures lacking this receptor, activation of ERK1/2 is likely to occur in response to both direct and indirect action of interleukin-1β on its target cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 921-932
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 921-932
نویسندگان
A. Nadjar, C. Combe, P. Busquet, R. Dantzer, P. Parnet,