کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9428890 | 1297016 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exploratory activity and spatial learning in 12-month-old APP695SWE/co + PS1/ÎE9 mice with amyloid plaques
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Exploratory activity and spatial learning in 12-month-old APP695SWE/co + PS1/ÎE9 mice with amyloid plaques Exploratory activity and spatial learning in 12-month-old APP695SWE/co + PS1/ÎE9 mice with amyloid plaques](/preview/png/9428890.png)
چکیده انگلیسی
APP695SWE/co + PS1/ÎE9 mice with Aβ plaques in neocortex and hippocampus were evaluated in tests of exploratory activity and spatial learning. On the initial testing day, 12-month-old APP695SWE/co + PS1/ÎE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP695SWE/co + PS1/ÎE9 mice were impaired during acquisition of the hidden platform subtask and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 390, Issue 2, 23 December 2005, Pages 87-92
Journal: Neuroscience Letters - Volume 390, Issue 2, 23 December 2005, Pages 87-92
نویسندگان
R. Lalonde, H.D. Kim, J.A. Maxwell, K. Fukuchi,