کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9428959 1297021 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parallel changes in gene expression in aged human and mouse cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Parallel changes in gene expression in aged human and mouse cortex
چکیده انگلیسی
The intensity of expression of over 20,000 genes and expressed sequence tags within the cerebral cortex has previously been described for both the human and mouse genomes. In both these species, the degree of expression of a relatively limited number of cortical genes, around 300, is significantly altered during senescence. The extent of similarity between age-related alterations of levels of specific mRNAs in either species has been compared. There is a significant correlation between species in those genes whose expression changes markedly in either direction with aging. This parallel serves to validate the use of mouse strains to study general age-related genetic events associated with aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 390, Issue 1, 16 December 2005, Pages 4-8
نویسندگان
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