کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429126 | 1297031 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alterations of membrane properties and effects of d-serine on NMDA-induced current in rat anterior cingulate cortex neurons after monoarthritis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Accumulated evidence implicates the anterior cingulate cortex (ACC) in pain processing. The activation of the NMDA receptor requires the occupation of both the glutamate site and the glycine site. d-Serine released by astrocytes is presumed to be an endogenous ligand for the glycine site of the NMDA receptor. Using whole-cell patch clamp recording, membrane characteristics and effects of exogenous d-serine on NMDA-evoked currents were examined in neurons in ACC slices from normal and complete Freund's adjuvant-induced monoarthritic rats. Neurons from rats with monoarthritis exhibited more depolarized membrane potential, lower firing threshold, lower input resistance and higher slope conductance compared with normal rats. The NMDA-evoked currents were enhanced by d-serine (20 μM) in both normal (135.3 ± 4.3% of control, p < 0.01) and arthritic (157.9 ± 9.7% of control, p < 0.01) rats, respectively. The effect of d-serine was greater in arthritic rats than control rats (p < 0.05). These results suggest that inflammatory pain increased the excitability of ACC neurons, and that the NMDA receptor glycine sites in the ACC neurons were not saturated in either normal or inflammatory pain states.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 384, Issue 3, 26 August 2005, Pages 245-249
Journal: Neuroscience Letters - Volume 384, Issue 3, 26 August 2005, Pages 245-249
نویسندگان
Ji-Dong Guo, Hua Wang, Yu-Qiu Zhang, Zhi-Qi Zhao,