کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9429450 1615205 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer's disease
چکیده انگلیسی
We compared magnetization transfer ratios (MTRs) in the brains of patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) to determine whether regional differences in the brain structures between DLB and AD are detectable with magnetization transfer imaging. Seventeen patients with DLB, 31 patients with AD and 18 elderly normal controls were included. Although no significant differences were found in MTRs in the frontal white matter between the three groups, MTRs in the hippocampus, parahippocampus, and posterior cingulate white matter in both patients with DLB and AD were significantly lower than those in age-matched control subjects. However, MTRs in the hippocampus of patients with DLB were significantly higher than those in patients with AD. Logistic regression analysis revealed that hippocampal MTR yielded a sensitivity of 76% and a specificity of 71% in discriminating DLB from AD. These results may reflect underlying histopathological differences with less severe neuronal degeneration in the hippocampus of DLB. MTR measurement of the hippocampus may contribute to the clinical differentiation between DLB and AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 380, Issues 1–2, 20–27 May 2005, Pages 166-169
نویسندگان
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