کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9429594 1297051 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Normal brain mitochondrial respiration in adult mice lacking cellular prion protein
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Normal brain mitochondrial respiration in adult mice lacking cellular prion protein
چکیده انگلیسی
Cellular prion protein (PrPc) gene (Prnp) null mice (Prnp0/0) show higher sensitivity to seizures, enhanced brain oxidative stress, and their neurons exhibit higher excitability “in vitro”. Mitochondrial respiration is a useful parameter for the determination of cellular metabolic rate and it is a major source of reactive oxygen species (ROS). In the present study, we investigated the mitochondrial function of different brain areas of Prnp0/0 adult mice and then compared this to normal control animals. Baseline mitochondrial respiration (stages 3 and 4), respiratory control ratio (RCR) and membrane potential were evaluated in the neocortex, entorhinal cortex, hippocampus, and cerebellum. No differences in these parameters were detected between Prnp0/0 and wild-type mice. Thus, we concluded that baseline mitochondrial respiration might not be directly related with the higher oxidative stress previously observed in brains from Prnp0/0 mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 375, Issue 3, 3 March 2005, Pages 203-206
نویسندگان
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