کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429594 | 1297051 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Normal brain mitochondrial respiration in adult mice lacking cellular prion protein
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Cellular prion protein (PrPc) gene (Prnp) null mice (Prnp0/0) show higher sensitivity to seizures, enhanced brain oxidative stress, and their neurons exhibit higher excitability “in vitro”. Mitochondrial respiration is a useful parameter for the determination of cellular metabolic rate and it is a major source of reactive oxygen species (ROS). In the present study, we investigated the mitochondrial function of different brain areas of Prnp0/0 adult mice and then compared this to normal control animals. Baseline mitochondrial respiration (stages 3 and 4), respiratory control ratio (RCR) and membrane potential were evaluated in the neocortex, entorhinal cortex, hippocampus, and cerebellum. No differences in these parameters were detected between Prnp0/0 and wild-type mice. Thus, we concluded that baseline mitochondrial respiration might not be directly related with the higher oxidative stress previously observed in brains from Prnp0/0 mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 375, Issue 3, 3 March 2005, Pages 203-206
Journal: Neuroscience Letters - Volume 375, Issue 3, 3 March 2005, Pages 203-206
نویسندگان
Bruno Lobão-Soares, Marino Muxfeldt Bianchin, Marcelo Neves Linhares, Cristiane Lima Carqueja, Carla Inês Tasca, Márcia Souza, Wilson Jr., Ricardo Brentani, Vilma R. Martins, Américo C. Sakamoto, Carlos Gilberto Jr., Roger Walz,