کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429674 | 1615203 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression analysis of psychological stress-associated genes in peripheral blood leukocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression analysis of psychological stress-associated genes in peripheral blood leukocytes Expression analysis of psychological stress-associated genes in peripheral blood leukocytes](/preview/png/9429674.png)
چکیده انگلیسی
In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2Â h before and 2 or 24Â h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compared with those prepared 4 weeks before the presentation. Hierarchical cluster showed that distinct groups of genes uniformly changed their expression values in response to the stress. Bayesian t test identified significantly up-regulated 49 genes and down-regulated 21 genes. Most of them are categorized into cytokines, cytokine receptors, growth- or apoptosis-related molecules, and heat shock proteins, suggesting that stressful life events trigger acute responses in leukocytes. Our results suggest that gene expression profile in peripheral blood leukocytes may be a potentially useful method for the assessment of complex stress responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 381, Issues 1â2, 10â17 June 2005, Pages 57-62
Journal: Neuroscience Letters - Volume 381, Issues 1â2, 10â17 June 2005, Pages 57-62
نویسندگان
Kyoko Morita, Toshiro Saito, Masayuki Ohta, Tetsuro Ohmori, Kaori Kawai, Shigetada Teshima-Kondo, Kazuhito Rokutan,