کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429717 | 1297056 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of a tumor necrosis factor gene polymorphism in Japanese patients with multiple system atrophy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
We studied promoter region polymorphisms in the tumor necrosis factor (TNF), interleukin (IL)-6, IL-10, and transforming growth factor (TGF)-β1 genes in Japanese patients with multiple system atrophy (MSA) (n = 122) and normal controls (n = 277). The frequency of the TNF-1031C, a high producer allele of TNF, was increased significantly in MSA patients compared with controls (Ï2 = 12.36, P = 0.0021, Pc = 0.0084). In contrast, there was no difference in the genotype or allele frequency in the other cytokine gene polymorphisms. We also failed to detect any difference in the disease onset between each genotype of the polymorphisms examined. Our findings suggest that TNF might have a toxic effect in MSA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 374, Issue 3, 21 February 2005, Pages 218-221
Journal: Neuroscience Letters - Volume 374, Issue 3, 21 February 2005, Pages 218-221
نویسندگان
Masataka Nishimura, Sadako Kuno, Ryuji Kaji, Hideshi Kawakami,