کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9436473 | 1615693 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disruption and restoration of cell-cell junctions in mouse vestibular epithelia following aminoglycoside treatment
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کلمات کلیدی
PBSPLSDHClPSCCSCLBCIPNBT5-bromo-4-chloro-3-indolylphosphate - 5-bromo-4-chloro-3-indolyl phosphateE-cadherin - E-CadherinAminoglycoside Ototoxicity - آمینوگلیکوزید OtotoxicityTight junction - اتصال تنگTem - این استphosphate buffer - بافر فسفاتprotected least significant difference - حفاظت شده حداقل تفاوت قابل توجهیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریTransmission electron microscopy - میکروسکوپ الکترونی عبوریNeomycin - نومیدینAdherens junction - پیوند پیوندهاInner ear - گوش داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Disruption and restoration of cell-cell junctions in mouse vestibular epithelia following aminoglycoside treatment Disruption and restoration of cell-cell junctions in mouse vestibular epithelia following aminoglycoside treatment](/preview/png/9436473.png)
چکیده انگلیسی
The intracellular junction complexes, which consist of tight junctions (TJ), adherens junctions (AJ), and desmosomes, mediate cell-cell adhesion in epithelial cells. E-cadherin, which is a major component of AJ, plays a role not only in the maintenance of cell-cell junctions, but also in repressing cell proliferation. In this study, we examined changes of E-cadherin expression in mouse vestibular epithelia following local application of neomycin using immunohistochemistry and western blotting, and morphology of cell-cell junctions by transmission electron microscopy (TEM). Immunohistochemistry and western blotting revealed down-expression of E-cadherin and its consecutive recovery. TEM demonstrated temporal disruption of cell-cell junctions. Morphology of cell-cell junctions was more rapidly restored than recovery of E-cadherin expression. Transient disruption of cell-cell junctions and down-expression of E-cadherin is a rational response for the deletion of dying hair cells, and may be associated with a limited capacity for cell proliferations in mammalian vestibular epithelia following their rapid restoration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 205, Issues 1â2, July 2005, Pages 201-209
Journal: Hearing Research - Volume 205, Issues 1â2, July 2005, Pages 201-209
نویسندگان
Tae-Soo Kim, Takayuki Nakagawa, Shin-ichiro Kitajiri, Tsuyoshi Endo, Shinji Takebayashi, Fukuichiro Iguchi, Tomoko Kita, Tetsuya Tamura, Juichi Ito,