کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9436655 | 1615692 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Eph proteins and the assembly of auditory circuits
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کلمات کلیدی
LSOMNTBAVCNGPiMGBMSOmedial geniculate body - اندام تناسلیephrin - اهرینAxon guidance - راهنمای آکسونlateral superior olive - زیتون برتر جانبیmedial superior olive - زیتون عالیAuditory nerve - عصب شنواییauditory pathways - مسیرهای شنواییnucleus magnocellularis - هسته magnocellularisnucleus laminaris - هسته لامیناریسmedial nucleus of the trapezoid body - هسته مرکزی بدن تراپزیanteroventral cochlear nucleus - هسته کچلیون anteroventralglycosyl-phosphatidylinositol - گلیکوزیل فسفاتیدیلینوزیتولEPH receptor - گیرنده EPH
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Many kinds of information are carried in the acoustic signal that reaches auditory receptor cells in the cochlea. The analysis of this information is possible in large part because of the neuronal architecture of the auditory system. The mechanisms that establish the precise circuitry that underlies auditory processing have not yet been identified. The Eph receptor tyrosine kinases and their ligands are proteins that regulate axon guidance and have been shown to contribute to the establishment of topographic projections in several areas of the nervous system. Several studies have begun to investigate whether these proteins are involved in the formation of auditory system connections. Studies of gene expression show that Eph proteins are extensively expressed in structures of the inner ear as well as in neurons in the peripheral and central components of the auditory system. Functional studies have demonstrated that Eph signaling influences the assembly of auditory pathways. These studies suggest that Eph protein signaling has a significant role in the formation of auditory circuitry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 206, Issues 1â2, August 2005, Pages 42-51
Journal: Hearing Research - Volume 206, Issues 1â2, August 2005, Pages 42-51
نویسندگان
Karina S. Cramer,