کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
944882 925727 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Executive function mediates effects of white matter hyperintensities on episodic memory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Executive function mediates effects of white matter hyperintensities on episodic memory
چکیده انگلیسی

This study examined the relationship between white matter hyperintensities (WMH) and executive functioning on episodic memory in a group of older adults who were cognitively normal or diagnosed with MCI or dementia. Volumetric magnetic resonance imaging (MRI) measures of total brain volume, white matter hyperintensity volume, and hippocampal volume along with age, education, and gender were evaluated as predictors of episodic memory. WMH were found to influence both episodic memory and executive functioning independently of other variables. The influence WMH on episodic memory was mediated by executive functioning and was completely eliminated when the interaction between executive functioning and hippocampal volume was entered in the regression model. The results indicate that executive functioning mediates the effects of WMH on episodic memory but that executive functioning and hippocampal volume can also interact such that executive functioning can exacerbate or ameliorate the influence of hippocampal volume on episodic memory.


► White matter hyperintensities (WMH) influence both episodic memory and executive function.
► Executive function completely mediates the influence of WMH on episodic memory.
► The influence of hippocampal volumes on episodic memory depends on executive function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 49, Issue 10, August 2011, Pages 2817–2824
نویسندگان
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