کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
945107 925756 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Noradrenergic stimulation and motor performance: Differential effects of reboxetine on movement kinematics and visuomotor abilities in healthy human subjects
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Noradrenergic stimulation and motor performance: Differential effects of reboxetine on movement kinematics and visuomotor abilities in healthy human subjects
چکیده انگلیسی

Evidence from studies in both animals and humans suggests that pharmacological stimulation of the noradrenergic system may modulate cortical excitability. However, the influence of such a modulation on the motor system remains unclear. We here explored the effects of noradrenergic stimulation on different motor tasks with increasing complexity and sensorimotor demands. Healthy human subjects received either reboxetine – a selective noradrenaline reuptake inhibitor – or placebo in a double-blind within-subject design. The analysis of movement kinematics revealed differential effects of RBX on subjects’ motor performance. While isolated stereotypic finger movements and simple reach-to-grasp movements did not change under RBX stimulation (compared to placebo), subjects showed a significant gain in movement speed in visuomotor tasks requiring online-control of precision movements. The results suggest that stimulating the noradrenergic system via RBX does not influence motor performance in general, but rather supports neural circuits involved in visuomotor control of movements.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 47, Issue 5, April 2009, Pages 1302–1312
نویسندگان
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